Publisher/s
Proceedings of the National Academy of Sciences
Publication Date
27 April 2025
Author
Sofia Carozza, Isaiah Kletenik, Duncan Astle, Amar Dhand

Note: This research paper is behind a paywall here, but the link below will take you to a summary article.

A Mass General Brigham study of over 9,000 participants showed that early life adversities correlate with diminished white matter connections, increasing risk for cognitive difficulties, but supportive relationships may offer protection.

White matter develops over the course of childhood in an experience-dependent manner. However, its role in the relationship between the early environment and later cognition is unclear, in part due to focus on changes in specific gray matter regions.

This study examines white matter differences across adolescents from diverse environments, evaluating both their extent throughout the brain and their contribution to cognitive outcomes. Using data from the Adolescent Brain Cognitive Development (ABCD) study (N = 9,082, female = 4,327), we found extensive cross-sectional associations with lower white matter fractional anisotropy (FA) and streamline count in the brains of 9- and 10-y-old children exposed to a range of experiences, including prenatal risk factors, interpersonal adversity, household economic deprivation, and neighborhood adversity.

Lower values of FA were associated with later difficulties with mental arithmetic and receptive language. Furthermore, white matter FA partially mediated the detrimental relationship between adversity and cognition later in adolescence. These findings advance a white matter-based account of the neural and cognitive effects of adversity, which supports leading developmental theories that place interregional connectivity prior to gray matter maturation.

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